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M9640758.TXT
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1996-03-04
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Document 0758
DOCN M9640758
TI Abnormalities of measles antibody response in human immunodeficiency
virus type 1 (HIV-1) infection.
DT 9604
AU Brunell PA; Vimal V; Sandu M; Courville TM; Daar E; Israele V; Ahmanson
Pediatric Center, Department of Medicine, Cedars-Sinai; Medical Center,
Los Angeles, California 90048, USA.
SO J Acquir Immune Defic Syndr Hum Retrovirol. 1995 Dec 15;10(5):540-8.
Unique Identifier : AIDSLINE MED/96142216
AB The finding that severe measles occurs in immunized as well as
nonimmunized human immunodeficiency virus (HIV)-infected individuals
suggests that both immunologic memory and the initial response to
measles may be impaired by HIV infection. That the initial response is
affected was supported by the finding that post-measles immunization
titers of HIV-infected babies were significantly lower (p = 0.01) than
those of normal babies. Poor immunologic memory was evidenced in
HIV-infected children by lower titers than in normal children (p <
0.001) and by a continuing decline in measles antibody that was not
arrested by reimmunization. Impaired memory appeared to be associated
with defective avidity maturation. HIV-infected babies and infants or
children had a significantly lower avidity index (AI) than age-matched
normal children (p < 0.01). HIV-infected adults, who were infected with
HIV following infection with measles, did not have AI values
significantly different from normal adults (p = 0.18) but had
significantly greater values than did HIV-infected babies and children
(p < 0.01). Thus, in contrast to infants and children who were infected
with HIV before measles immunization, the adult immune response to
measles was less affected.
DE Adult Antibodies, Viral/*BIOSYNTHESIS Antibody Affinity Child Child,
Preschool CD4 Lymphocyte Count Enzyme-Linked Immunosorbent Assay
Human HIV Infections/*COMPLICATIONS *HIV-1 Immunization
Immunization, Secondary Immunologic Memory Infant
Measles/*IMMUNOLOGY/PREVENTION & CONTROL Measles Vaccine/ADMINISTRATION
& DOSAGE/IMMUNOLOGY Measles Virus/*IMMUNOLOGY Mumps
Vaccine/ADMINISTRATION & DOSAGE/IMMUNOLOGY Rubella
Vaccine/ADMINISTRATION & DOSAGE/IMMUNOLOGY Support, U.S. Gov't, P.H.S.
Vaccines, Combined/ADMINISTRATION & DOSAGE/IMMUNOLOGY JOURNAL ARTICLE
SOURCE: National Library of Medicine. NOTICE: This material may be
protected by Copyright Law (Title 17, U.S.Code).